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By email : Bernard Vanhove

Academic partnerships aimed at scientific collaboration, and financial support to conduct research programs

OSE Immunotherapeutics benefits from an international network that offers access to the best experts in immunotherapy and transplantation, due to historic academic relationships.

Partnerships in basic research are currently conducted:

  • In Europe with the European Center for Sciences in Transplantation and Immunotherapy (CESTI) (which brings together the clinical teams of the University Hospital Institute and the teams of the INSERM Center for Research in Transplantation and Immunology – CRTI – INSERM 1UMR064), the Regional University Hospital and the University of Nantes, other French CNRS or INSERM teams, the « Children’s Cancer Research Institute » of Vienna (Austria), the “Biomedical Primate Research Center” in Netherlands and the Oxford University,
  • In the U.S. with the Maryland University in Baltimore and the « Ben Towne Center for Childhood Cancer Research » in Seattle (Washington).

This international network of excellence has resulted in promising data having been published in key scientific publications, resulting in increased visibility of the company’s achievements (Poirier et al. Science Translational Médicine 2010).

OSE Immunotherapeutics is supported by major institutional organizations : Pays de la Loire Territoires d’Innovation, Atlanpole Biothérapies, Bpifrance, and by national funding : « Prime d’aménagement du territoire », a funding for regional development.

OSE-127 (Effi-7), Interleukin-7 Antagonist (IL-7R), developed in autoimmune diseases through the consortium EFFIMab

OSE-127 (Effi-7) is a humanized monoclonal antibody targeting CD 127 receptor, the alpha chain of the Interleukin 7 receptor (IL-7R), with proof of concept confirmed in vivo in several auto-immune models.

This collaborative program, co-financed by Bpifrance, is headed by OSE Immunotherapeutics as leader of the consortium to develop OSE-127 (Effi-7), a monoclonal immunomodulatory antibody targeting the CD127 receptor, the alpha chain of the interleukin-7 receptor (IL-7R).

The product is under preclinical phase in ulcerative colitis and the funding from Bpifrance will enable to cover its development until the phase 2 clinical stage. The total amount of the OSE-127 program, being developed by OSE Immunotherapeutics in collaboration with INSERM and Nantes University Hospital, is of €20 million with €9.1 million allotted by Bpifrance.

In June 2017, the Company announced a new milestone related to the finalization of significant preclinical results for OSE-127 and translational data on the high expression of IL-7R in biopsies from patients with ulcerative colitis These data will be used to support the next clinical applications planned in inflammatory bowel diseases (results presented at the international congress of immunology of FOCIS – Federation of Clinical Immunology Societies * – Press release of June 15, 2017). In addition, the manufacturing process of OSE-127 is finalized, making it possible to advance towards pilot batch production step.

* “IL-7 pathway controls human T cell homing to the gut and culminates in inflammatory bowel disease mucosa”

OSE-703 (Effi-3), a cancer therapy targeting IL-7R, under a strategic multi-year research collaboration with Memorial Sloan Kettering Cancer Center in New York

OSE-703 (Effi-3) is a humanized cytotoxic monoclonal antibody directed against the extracellular domain of the alpha-chain of the receptor for interleukin-7 (CD127), cytotoxic for human cells expressing CD127.

In June 2017, the Company has entered into a multi-year research collaboration on OSE-703, a therapy targeting IL-7R, with Memorial Sloan Kettering Cancer Center (MSK) in New York.

The research program is conducted by physician-scientist Prasad S. Adusumilli, MD, FACS, a thoracic surgeon with expertise in tumor immunology and a focus on the development of chimeric antigen receptor T-cell (CAR T-cell) immunotherapy.

The goal of this research collaboration is to explore IL-7R directed immunotherapy OSE-703 for solid tumors with non-small cell lung cancer (NSCLC) as the primary cancer model. From a large cohort of NSCLCs*, it has been shown that IL-7R was overexpressed in this type of cancer and associated with poor prognosis.

* Suzuki et al, J Clin Oncol. 2013 Feb 1; 31(4): 490–498.

OSE-172 (Effi-DEM), a new generation immune checkpoint inhibitor targeting suppressor myeloid cells via SIRPα receptor, developed in immuno-oncology through EFFI-CLIN collaborative program

Tumours have the particularity of secreting molecules that allow the recruitment and/or generation of suppressor cells that prevent the immune system from eliminating tumour cells. Among the major players in immune dysfunctions promoting tumour growth, pro-tumour and suppressor myeloid cells have been identified (MDSC or Myeloid-Derived Suppressor Cells / TAM or Tumour-Associated Macrophages).

OSE Immunotherapeutics was the first to identify the SIRP-alpha target (Signal Regulatory Protein alpha) as a major checkpoint for myeloid cells. The company has developed a selective SIRP-alpha antagonist antibody that transforms the tumour microenvironment by blocking suppressor cells and activating anti-tumour effector cells.

In July 2017, the Company has received €9.2 million grant from the “Projets de R&D Structurants Pour la Compétitivité” (PSPC) of the “Invest in the Future Program” (PIA). This program is overseen by the General commissariat of investment (CGI) and led by Bpifrance.

OSE Immunotherapeutics leads the consortium collaborating on this project named EFFI-CLIN aiming at developing a new generation of checkpoint inhibitor in cancer immunotherapy. The consortium also includes the European Center for Transplantation and Immunotherapy (CESTI), a public organization based in Nantes (France) and HISTALIM, a SME based in Montpellier (France).

EFFI-CLIN will evaluate the safety and the clinical efficacy of new cancer immunotherapy OSE-172 as a monotherapy and in combination in various indications where myeloid cells represent a poor prognosis factor. The project will include in particular the product manufacturing compliant with pharmaceutical standards, translational studies conducted from tumour tissues to measure the presence of immunological targets including SIRP-alpha, and a clinical program planned until the phase 2.