However, immune activation and regulation target very similar receptors of immune cells. In order to fight cancer, the body’s immune system is activated to attack a target. In contrast, in autoimmune diseases or in anti-rejection treatment following organ transplantation, the activation of the immune system has to be regulated or inhibited.
In terms of immune response, the same immunological targets and immune cells may be involved as mechanisms of stimulation and tolerance. Understanding these targets and their specific roles enables the identification of compounds capable of optimized stimulation or regulation depending on the immune function to be restored in a selected pathology.
OSE Immunotherapeutics identifies and validates new therapeutic targets and develops them in various models of therapeutic interest in immunology: cancer, autoimmune diseases, and transplantation.