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Immuno-Oncology

Immuno-Oncology

Immuno-Oncology Pipeline

OSE Immunotherapeutics’ immuno-oncology pipeline is comprised of four programs, three of which are currently in clinical status.

The most advanced program is its Phase 3 trial with TEDOPI®, a patented combination of 10 neo-epitopes. Tedopi® is being evaluated in non-small cell lung cancer (NSCLC) after checkpoint inhibitor failure.

A Phase 2 is ongoing in pancreatic cancer in collaboration with the GERCOR, a leading clinical research association that includes 300 cancer centers in France.

OSE Immunotherapeutics is also investigating BI 765063 (OSE-172), a first-in-class myeloid checkpoint inhibitor targeting the SIRPα / CD47 receptor pathway. BI 765063 is currently under Phase 1 clinical trial in advanced solid tumors under a license and collaboration agreement with Boehringer Ingelheim .

The Company develops a bispecific fusion protein platform (BiCKI®) built on the key backbone component anti-PD-1 (OSE-279), a novel standard of care treatment in oncology and paired with innovative immunotherapy targets. The BiCKI® platform strives to inhibit key immune checkpoints while simultaneously delivering intratumoral cytokines with Treg modulating function and/or increasing exhausted T cell responses.

Several new pipeline candidates should emerge in the near future in the immuno-oncology area.

Program
Indication
Preclinical
Phase 1
Phase 2
Phase 3
Partners
IMMUNO-ONCOLOGY
Tedopi®
Neo-Epitopes
NSCLC
Positive Step-1 results; primary endpoint met
Tedopi®
Neo-Epitopes
Advanced pancreatic cancer
Combo with PD1 Opdivo® ongoing
BI 765063 (OSE-172)
SIRPα
Advanced solid tumours
Ongoing
BiCKI®
Bi-specific anti-PD-1 & Innovative targets
Various cancers
2020

Program

  • Indication NSCLC
  • Pre-Clinical POC
  • Phase 1
  • Phase 2
  • Phase 3 Positive Step-1 results; primary endpoint met
  • Partners
  • Indication Advanced pancreatic cancer
  • Pre-Clinical POC
  • Phase 1
  • Phase 2 Combo with PD1 Opdivo® ongoing
  • Phase 3
  • Partners
  • Indication Advanced solid tumours
  • Pre-Clinical POC
  • Phase 1 Ongoing
  • Phase 2
  • Phase 3
  • Partners
  • Indication Various cancers
  • Pre-Clinical POC 2020
  • Phase 1
  • Phase 2
  • Phase 3
  • Partners
  • BI 765063 (OSE-172)

    +
  • Tedopi®

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  • BiCKI®

    +