Publications scientifiques

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2024 OSE279, a PD-1 blocking monoclonal antibody, as future backbone of a bifunctional checkpoint inhibitor platform: preliminary results of a First-In-Human (FIH) study in subjects with advanced malignancies, ESMO Targeted Anticancer Therapies 2024
2023 Antagonist antibodies inhibiting the binding of myeloid checkpoint CLEC-1 to novel endogenous ligands demonstrate high anti-tumor efficacies in humanized preclinical models, SITC 2023
2023 Anti-PD-1/IL-7v immunocytokine (BICKI®IL7v) favors proliferation & survival of TCF1+ stem like memory T cells and a durable in vivo efficacy in monotherapy or using combinatorial strategies, CICON 2023
2023 Open-label, Phase I dose escalation/expansion trial of the anti-SIRPa monoclonal antibody BI 770371 in patients with advanced solid tumours, alone or in combination with the anti-PD-1 monoclonal antibody ezabenlimab, ESMO 2023
2023 OSE-279, a PD-1 blocking monoclonal antibody, as future backbone of a bifunctional checkpoint inhibitor platform: Preclinical characterization and early clinical results of a First-In-Human (FIH) study in subjects with advanced malignancies, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2023
2023 ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression, Frontiers in Immunology, July 2023
2023 Agonist anti-ChemR23 mAb inhibits NETosis and neutrophil-mediated inflammation, FOCIS 2023
2023 TRIM21 is a novel endogenous partner of the inhibitory myeloid checkpoint CLEC-1 involved in tumor antigen cross-presentation, American Association for Cancer Research (AACR) 2023
2023 Blockade of the myeloid CLEC-1 checkpoint enhances antitumor responses and tumor antigen cross-presentation, American Association for Cancer Research (AACR) 2023
2023 CD127 is expressed by acute lymphoblastic leukemias and is efficiently targeted by Lusvertikimab (OSE-127) through IL-7Rα blockade and antibody dependent phagocytosis, American Association for Cancer Research (AACR) 2023
2023 Anti-PD-1/IL-7v bispecific antibody (BICKI®IL7v) promotes TCF1+ stem like T cells expansion and long-lasting in vivo efficacy, American Association for Cancer Research (AACR) 2023
2023 Predictive response biomarkers from a Phase I clinical trial of a SIRPalpha inhibitor, BI 765063, stand-alone and in combination with ezabenlimab, a PD-1 inhibitor, in patients with advanced solid tumors, American Association for Cancer Research (AACR) 2023
2023 First-in-Human Study in Healthy Subjects with the Non-Cytotoxic 1 Monoclonal Antibody OSE-127, a Strict Antagonist of the IL-7Rα, Journal of Immunology, Feb. 2023
2022 "CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy", Science Advances, Nov. 2022
2022 “IL7R TME expression correlates with immunotherapy response and is associated with T-cell stemness with decreased apoptosis”, SITC 2022
2022 “Anti-PD-1/IL-7v bispecific antibody promotes TCF1+ stem like T-cells expansion and long-lasting in-vivo efficacy”, SITC 2022
2022 “Blockade of the myeloid CLEC-1 checkpoint enhances antitumor responses and tumor antigen cross-presentation”, SITC 2022
2022 "Net Treatment Benefit of OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO) in Phase 3 Atalante-1 randomized trial", ESMO 2022
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