Publications Scientifiques

• Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in class BI 765063, a selective SIRPα inhibitor: results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors

  American Society of Clinical Oncology (ASCO) 2021
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• Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance

  J Clin Invest. 2020
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• SIRPα/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid‐derived suppressor cells

  Am J Transplant. 2019
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• Selective SIRPa blockade potentiates dendritic cell antigen cross-presentation and triggers memory T-cell antitumor responses

  Poster AACR (2018)
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• SIRPa inhibition monotherapy leads to dramatic change in solid tumor microenvironment and prevents metastasis development

  Poster AACR (2018)
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• The Dual Role of Myeloid-Derived Suppressor Cells in Liver Pathologies

  J Liver Clin Res 1(1): 1001 (2014)
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• Increase in CD14+HLA-DR2/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis

  Cancer Immunol Immunother 62:1421–1430 (2013)
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• Dual targeting of adaptive and innate checkpoints induce potent memory anti-tumor response

  Poster EACR (2016)
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• Control of immune tolerance by the SIRPα – CD47 pathway and Myeloid-Derived Suppressor Cells

  Poirier N. et al. - Poster EACR (2016)
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• Selective targeting of the SIRPα immune checkpoint, but not CD47, controls the polarization of macrophages

  Poster Philadelphie & EACR (2016)
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