Publications Scientifiques

• Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

  Poirier et al, Science Transl Med 2010
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• CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

  Watkins et al, JCI 2018
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• Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a non-human primate model of collagen-induced arthritis

  Vierboom et al., Clin Exp Immunol. 2016
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• Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection

  Ville et al, J Am Soc Nephrol 2016
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• Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses

  Zaitsu M. et al.; Journal of Clinical Investigation (2017)
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• Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection

  Journal of the American Society of Nephrology (2016)
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• First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28

  Poirier N. et al.; Journal of Immunology (Nov. 2016)
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• CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity

  Dillinger B. et al.; Frontiers in Immunology (2017)
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